Variations in oxidative stress and antioxidant defense level during different phases of hibernation in common Asian toad, Duttaphrynus melanostictus

To assess redox status during hibernation with metabolic depression, oxidative stress parameters and antioxidant defense were assessed during different phases of hibernation including active period, hibernation, arousal, and post-arousal period, in the liver and brain tissues of Duttaphrynus melanostictus.We hypothesized low levels of oxidative str

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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab to chemotherapy plus trastuzumab as neoadjuvant therapy

BackgroundHuman epidermal growth factor receptor 2(HER-2) is the most prominent therapeutic target for gastric (G)/gastroesophageal junction (GEJ) cancer.Guidelines recommend its use for treating G/GEJ cancers.However, targeted therapy did not significantly improve survival outcomes compared to those with neoadjuvant therapy.The KEYNOTE-811 trial r

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